Epigenetics is Back! HSP90 and Phenotypic Variation
نویسندگان
چکیده
منابع مشابه
Epigenetics as an explanation for phenotypic variation in monozygotic twins
Researchers often use twins as natural samples to test hypotheses regarding the contribution of genetic factors to different phenotypes, especially diseases. The classical method is comparing traits in identical, or monozygotic (MZ) twins to those of dizygotic (DZ) twins. This method has had a significant impact on our current understanding of etiologic factors in many diseases which do not fol...
متن کاملHSP90-buffered genetic variation is common in Arabidopsis thaliana.
HSP90 is a protein chaperone particularly important in the maturation of a diverse set of proteins that regulate key steps in a multitude of biological processes. Alterations in HSP90 function produce altered phenotypes at low penetrance in natural populations. Previous work has shown that at least some of these phenotypes are due to genetic variation that remains phenotypically cryptic until i...
متن کاملUncovering the contribution of epigenetics to plant phenotypic variation in Mediterranean ecosystems.
Epigenetic signals can affect plant phenotype and fitness and be stably inherited across multiple generations. Epigenetic regulation plays a key role in the mechanisms of plant response to the environment, without altering DNA sequence. As plants cannot adapt behaviourally or migrate instantly, such dynamic epigenetic responses may be particularly crucial for survival of plants within changing ...
متن کاملAdmixture and clinical phenotypic variation.
All human populations exhibit some level of genetic differentiation. This differentiation, or population stratification, has many interacting sources, including historical migrations, population isolation over time, genetic drift, and selection and adaptation. If differentiated populations remained isolated from each other over a long period of time such that there is no mating of individuals b...
متن کاملThe Phenotypic variation of Candida albicans and susceptibility to fluconazole and voriconazole
Candida albicans is the most frequent opportunistic fungal agent in human being. One of its virulence factors is phenotypic switching. In this study, we investigated the susceptibility of different phenotypes of C. albicans, obtained from clinical specimens, to fluconazole (FLZ) and voriconazole (VRZ) with microdilution reference method. In this study, 281 C. albicans of six different phenotype...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2003
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.2.1.274